Ceftiofur Hydrochloride (103980-44-5)
Sharaxaada Alaabta
Ceftiofur waa antibiyootiko ka mid ah nooca cephalosporin (jiilka saddexaad), oo shatiyaysan in loo isticmaalo daawaynta xoolaha.Waxaa markii ugu horreysay lagu sharraxay 1987-kii.
Waxay u adkaysataa antibiyootiga iska caabinta enzyme beta-lactamase, waxayna leedahay hawl ka dhan ah bakteeriyada Gram-positive iyo Gram-negative.Noocyada E. coli ee u adkaysta ceftiofur ayaa la soo sheegay.
Ceftiofur Hydrochloride waa qaabka cusbada hydrochloride ee ceftiofur, semisynthetic, beta-lactamase-stable, spectrum ballaaran, cephalosporin jiilka saddexaad oo leh firfircooni bakteeriyada.Ceftiofur waxay ku xidhaa oo ay hawlgelisaa borotiinnada penicillin-ku xidha (PBPs) ee ku yaal xuubka gudaha ee gidaarka unugyada bakteeriyada.PBPs waa enzymes ku lug leh marxaladaha ugu dambeeya ee isu-ururinta derbiga unugyada bakteeriyada iyo dib-u-qaabaynta derbiga unugyada inta lagu jiro koritaanka iyo kala qaybinta.Dhaqdhaqaaq la'aanta PBP-yada waxay faragelisaa isku-dhafka silsiladaha peptidoglycan ee lagama maarmaanka u ah xoogga gidaarka unugyada bakteeriyada iyo adkaanta.Tani waxay keenaysaa daciifinta gidaarka unugyada bakteeriyada waxayna sababtaa lysis unug.
| WAXYAABAHA | QAABKA | NATIIJADA | |
| Muuqashada | Budada Crystalline ee cad ama Off-caddaan | U hoggaansamo | |
| Aqoonsiga | Waqtiga haynta ee ugu sarreysa maamulaha ee chromatogram oo lagu helay xalka tijaabada waxay la mid tahay kan ugu sarreeya ee ugu sarreeya chromatogram oo lagu helay xal tixraaceed. | U hoggaansamo | |
| Falcelinta chloride | U hoggaansamo | ||
| Muuqashada xalka | Caddayn | Aan ka xoog badnayn No.1 Turbidity Standard | <1 |
| Midabka | Aan ka madaw ahayn xalka caadiga ah Y9 | <8 | |
| Solubility | Ku milmay N, N- Dimethylacetamide, wax yar ku milmay 5% sodium bicarbonate iyo methanol. | U hoggaansamo | |
| PH | 2.0 ~ 3.0 | 2.2 | |
| Waxyaalaha biyaha | 1.5% ~ 4.0% | 1.6% | |
| Wareegga indhaha ee gaarka ah | -115°~-127° | -117° | |
| Bir culus | NMT 0.0020% | U hoggaansamo | |
| Hadhaaga dabka | NMT 0.20% | 0.15% | |
| Walxaha la xidhiidha | Nijaasta ugu weyn | NMT 0.20% | 0.09 |
| Wadarta wasakhda | NMT 1.50% | 0.38 | |
| Haraaga dareerayaasha | Ethyl acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0.006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0.0001 | |
| Qiimayn | Ceftiofur Hydrochloride | NLT 98.0% | 100.4% |
| Chloride | 6.0% ~ 6.5% | 6.2% | |
| Bakteeriyada Endotoxin | In ka yar 0.20EU/mg | U hoggaansamo | |
| Madhalaysnimo | U hoggaansamaya imtixaanka | U hoggaansamo | |
| Cabbirka walxaha | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| GUNAANAD | Natiijooyinka imtixaanku waxay waafaqsan yihiin qeexitaanka | ||
