Tranexamic acid (1197-18-8)
Sharaxaada Alaabta
● Tranexamic acid (1197-18-8)
● CAS No.:·1197-18-8
● EINECS Lambarka: 356.2222
● MF: C8H15NO2
● Xidhmada: 25Kg/Drum
● Tranexamic acid (TXA) waa daawo loo isticmaalo in lagu daweeyo ama looga hortago dhiigbax xad dhaaf ah oo ka yimaada dhaawacyada waaweyn, dhiigbaxa umusha ka dib, qalliin, ilig laga saaro, dhiig sanka, iyo caadada culus.[2][3]Waxa kale oo loo isticmaalaa xanuunka anjioedema ee la iska dhaxlo.[2][4]Waxa laga qaataa afka ama irbad xididka.
Habka wax-qabadka
Tranexamic acid waa analoogga synthetic ee amino acid lysine.Waxay u adeegtaa sidii antifibrinolytic iyada oo dib u celinaysa ku xidhaysa afar ilaa shan goobood oo lysine reseptor ah oo ku yaal plasminogen.Tani waxay hoos u dhigaysaa u beddelka plasminogen una beddelo plasmin, ka hortagga xaalufka fibrin iyo ilaalinta qaabka qaabdhismeedka matrixka fibrin. waxqabadka plasmin oo leh awood daciif ah (IC50 = 87 mM), waxayna xannibi kartaa goobta firfircoon ee urokinase plasminogen activator (uPA) oo leh gaar gaar ah (Ki = 2 mM), mid ka mid ah kuwa ugu sarreeya dhammaan proteases serine.
Tranexamic acid wuxuu u shaqeeyaa
Aashitada Tranexamic ayaa inta badan la isticmaalaa ka dib dhaawacyada waaweyn.[13]Tranexamic acid waxa loo isticmaalaa in lagaga hortago laguna daweeyo luminta dhiiga xaalado kala duwan, sida hababka ilkaha, dhiigbaxa caadada oo culus, iyo qaliino leh khatar sare oo dhiig lumi.
| Walxaha Imtixaanka | Shuruudaha Pharmacopeial | Natiijada Imtixaanka | |
| MEESHA | Muuqashada: Caddaan ama ku dhawaad cad, budada crystalline | Budada crystalline cad | |
| Solubility: Si xor ah ugu milmay biyaha iyo glacial acetic acid, ficil ahaan aan lagu milmi karin acetone iyo ethanol (96%) | Gudub | ||
| AQOONSIGA | Spectrophotometry Nuugista Infrared: IR spectrum waxay la socotaa Tranexamic acid CRS | Gudub | |
| TIJAAB | pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Walxaha laxidhiidha (HPLC2.2.29) | wasakh A≤ 0.1 % | Lama ogaan | |
| Xumaan B≤ 0.2% | 0.03% | ||
| wasakhdaC wasakhda aan la cayimin≤ 0.10% wasakhda D Waxyaalaha kale ee wasakhda ah | 0.002% 0.001% Lama ogaan | ||
| Wadarta wasakhda aan la cayimin≤ 0.2% | 0.003% | ||
| Halides waxaa loo muujiyey sida koloriin | ≤140pm | <140pm | |
| Khasaare xagga qalajinta | ≤0.5% | 0.026% | |
| Sulfated Ash | ≤0.1% | 0.027% | |
| ASSAY | Waa inuu ku jiraa (kusalaysan qalalan) 99.0% 〜101.0% | 100.1% | |
