Doxycycline Hyclate (24390-14-5)
Sharaxaada Alaabta
● Doxycycline Hcl waa bakteeriyada bakteeriyada waxay aad ugu dhowdahay Tetracycline iyo Terramycin, laakiin waxay leedahay saameyn wanaagsan, u nugul Staphylococcus Aureus ee tetracycline u adkeysiga, oxytetracycline, waqti dheer waarta caabuq sambabada, qumanka ba'an, mycoplasma pneumonia, caabuqa kaadi mareenka, sumowga dhiiga, dysentery bacillary, lymphadenitis ba'an, iwm. Aad bay caan ugu tahay bukaanka nephropathy sababtoo ah sunta aan caddayn ee kelyaha.
● Doxycycline Hyclate waa milixda hyclate ee doxycycline, synthetic, antibiyootiko tetracycline ballaaran oo muujinaya firfircoonida ka hortagga jeermiska.Doxycycline hyclate waxay si isdaba joog ah ugu xidhan tahay qaybta 30S ee ribosomal, lagana yaabo inay ku xidho 50S ribosomal subnit sidoo kale, taas oo xannibaysa isku xidhka aminoacyl-tRNA ee isku xidhka mRNA-ribosome.Tani waxay keenaysaa in la joojiyo isku-darka borotiinka.Intaa waxaa dheer, wakiilkani wuxuu soo bandhigay xannibaadda dhaqdhaqaaqa collagenase.
Codsiga
Doxycycline Hyclate waxaa loo isticmaalaa in lagu daweeyo noocyo badan oo caabuq bakteeriyada ah, oo ay ku jiraan kuwa keena finanka.Doxycycline Hyclate ayaa sidoo kale loo isticmaalaa si looga hortago duumada.Doxycycline Hyclate waxaa loo yaqaanaa antibiyootiga tetracycline.Waxay ka shaqeysaa joojinta koritaanka bakteeriyada. Antibiyootiggani wuxuu daaweeyaa kaliya caabuqyada bakteeriyada.
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Budada crystalline jaalaha ah | waafaqsan |
| Aqoonsiga | TLC | waafaqsan |
| falcelinta sulfuric acid midab huruud ah ayaa soo baxa | waafaqsan | |
| waxay ka hortagtaa chlorides | waafaqsan | |
| PH | 2.0 ~ 3.0 | 2.3 |
| Nuugista gaarka ah | at 349nm e (1%) 300 ~ 355 | 320 |
| Wareegga indhaha ee gaarka ah | -105 ~ -120° | -110° |
| Biraha culus: | ≤50pm | <20pm |
| Wasakhyada iftiinka nuugaya | at 490nm ≤0.07 | 0.03 |
| Walxaha la xidhiidha | 6-epidoxycycline ≤2.0% metacycline ≤2.0% 4-epidoxycycline ≤0.5% (ep5) 4-epi-6-epidoxycycline ≤0.5% (ep5) Oxytetracycline ≤0.5% (ep5) wasakh kale ≤0.5% wasakhda aan la aqoonsan ≤0.1% (ep5) | 1.6%0.1% Lama helin Lama helin Lama helin Lama helin Lama helin |
| Ethanol | 4.3 ~ 6.0% (m/m) | 4.5% |
| dambaska sulphateed | ≤0.4% | 0.05% |
| Biyo | 1.4 ~ 2.8% | 1.8% |
| Qiimayn | 95.0 ~ 102.0% (c22h25cln2o8) oo ku salaysan anhydrous, walax aan ethanol lahayn | 98.6% |
| Gabagabo | La jaanqaadka USP32 | |
