Glucose-6-phosphate dehydrogenase (G6PDH)

Glucose 6 phosphate dehydrogenase (G6PD) yaraanta waa xaalad la iska dhaxlo oo unugyada cas cas ay burburaan (hemolysis) marka jirku soo gaaro cuntooyinka qaarkood, daawooyinka, caabuqyada ama walbahaarka.Waxay dhacdaa marka qofku maqan yahay ama uu leeyahay heerar hoose oo ah glucose-6-phosphate dehydrogenase.Enzyme Tani waxay caawisaa unugyada cas cas ee dhiigga inay si habboon u shaqeeyaan.Astaamaha inta lagu jiro marxaladda hemolytic waxaa ka mid noqon kara kaadi madow, daal, midabka midabka, garaaca wadnaha oo degdeg ah, neefta oo gaaban, iyo maqaarka oo jaale ah (cagaarshow).yaraanta G6PD waxa lagu dhaxlaa hab dib-u-dhac ku xidhan ee X-calaamadahana waxay ku badan yihiin ragga (gaar ahaan Afrikaan Ameerikaanka iyo kuwa ka yimid qaybo ka mid ah Afrika, Aasiya, iyo Mediterranean-ka).Waxaa sababa isbeddellada hidde-sidaha ee G6PD.

Glucose-6-Phophate Dehydrogenase (G-6-PDH) waxay ka kooban tahay laba qaybood oo miisaan kelli ah oo u dhigma.Taxanaha amino acid ee monomer ayaa la daabacay.G-6-PDH ayaa loo adeegsaday baaritaannada nicotinamide adenine dinucleotide iyo unugga pyridine nucleotides.G-6-PDH waxa dib looga hawlgelin karaa xalalka urea-denatured.

Glucose 6-fosfate dehydrogenase waa ensaym nidaamiye fure u ah tallaabada ugu horreysa ee dariiqa fosfatka pentose.G-6-P-DH waxay oxidizes gulukoos-6-fosfateet iyadoo ay jirto NADP⁺ si loo helo 6-phosphogluconate.Polyacrylamide gel electrophoresis, midabaynta dhaqdhaqaaqa, iyo ka-hortagga khamiirka G-6- PDH cilmi-baarista difaaca jirka ayaa muujisay in G-6-PDH uu yahay glycoprotein.